Cancer now is one of the biggest killers of man, with one out of two and three men and women, respectively, currently expected to be diagnosed with some form of cancer during his / her lifetime. Although great advances are being made in the clinical management of cancer all the time, there is still significant unmet need as regards early, definitie, functional diagnoses and long lasting, non-toxic effective therapies. In these regards, ion channels and transporters offer much potential as novel targets. Although such mechanisms are traditionally investigated by biophysicists, physiologists, cell and molecular biologists, clinicians are steadily being attracted into this exciting new field. Indeed, in recent years, both the National Cancer Institute (USA), Cancer Research (UK) and national and international research councils have issued calls for physical scientists and engineers to get involved in cancer research (see http://www.epsrc.ac.uk/newsevents/pubs/the-importance-of-engineering-and-physical-sciences-research-to-health-and-life-sciences/). The current state of the art was marked last year with the publication of a Theme Issue of the Philosophical Transactions of the Royal Society (http://rstb.royalsocietypublishing.org/content/369/1638).
Topics to be covered (not exclusive)
Primary tumourigenesis (cell cycle), metastasis, cellular adhesion, directional motility, invasion, angiogenesis, sodium channels, potassium channels, chloride channels, volume control, calcium signalling, Trp channels, hypoxia, oxidative stress, pH regulation, proteases, neurotransmitter receptors, hormones, growth factors, systems pathobiology, diagnostic / prognostic markers, drug development.